Toulouse 0-0 Benfica
(Benfica lolos agregat 2-1)
Qarabag FK 2-3 SC Braga
(Qarabag FK lolos agregat 6-5)
Sparta Praha 4-1 Galatasaray
(Sparta Praha lolos agregat 6-4)
Sporting Lisbon 1-1 Young Boys
(Sporting Lisbon lolos agregat 4-2)
Marseille 3-1 Shakhtar Donetsk
(Marseille lolos agregat 5-3)
AS Roma 1-1 Feyenoord Rotterdam
(AS Roma lolos agregat 2-2)***